My point was there are no specific safety trials because they measure effectiveness and safety concurrently. How would a safety specific trial differ from the current standard?
Discussion
Have you actually not looked at the trials? They explicitly separate them and are required to for pre approval trials. The details of each can be found in all of the package inserts.
Yes. Here is the package insert for Pfizer https://www.fda.gov/media/151707/download the safety data is on pages 6-21. It’s all the same trials they just separate the data because efficacy and safety are concerned with different data points.
Later package inserts got updated safety data once they learned about further risks for specific populations.