You can easily create those feeds using Primal advanced search. Just add all the hashtags/keywords into your search query and save the search.

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But do I need to change the config every time I want a new multi # feed

Yes. Each would be a different search query and therefore a different feed.

This is the problem. It’s better if is a permanent created feed

You can add the ability to search only for posts without replies. I currently use primal exclusively with feeds created by me via advanced search, but for some feeds it's really annoying to have replies included as well.