So do them, and avoid camelcase for the mystery element!

Agreed! Also may I ask, are hashtags a thing here?

Corporations, driven by profits, often overlook ethical considerations.

#Merck exemplifies this issue.

Here are three ways it’s putting profits over people right now.

1⃣ #GARDASIL is a great vaccine. So great, in fact, that a single dose offers solid protection against HPV cancers.

Yet in spite of the WHO’s recommendation and substantial evidence for the efficacy of 1 dose, Merck promoted 2 doses at this year’s IPVC.

Colleague Cameron B. Haas explains: Merck constrained its statistical models so 1 HPV dose could never outperform 2 doses. But there’s no justification for this assumption: more jabs give more antibodies, but this doesn’t necessarily translate to better protection.

It’s worth noting Merck manufactured insufficient quantities of overpriced HPV vaccine for years. Folks from low-income countries have lacked access. Cervical cancer is preventable but not prevented — due in part to corporate-driven inequities.

2⃣ #MOLNUPIRAVIR (MOV). Merck obtained emergency approval for MOV in December 2021 — just barely the first oral antiviral against COVID-19.

But MOV works by causing viral #mutations, the raw material for new variants of concern.

Weeks before the US FDA decision on MOV, numerous scientists identified issues with Merck’s statistical analyses, the risks posed to individual patients, and the risks for viral evolution.

Unfortunately, MOV was recommended 13-10. Merck’s case to the FDA repeatedly confused mutation and selection, arguing that all drugs impose selection. But the problem is mutation: MOV potentiates rare but impactful ‘black swan’ variants.

Concerns about MOV’s risks have laladly been validated. For example, work by Theo Sanderson and colleagues shows elevated — but sublethal — mutations in viral genomes, consistent with MOV, in regions where it’s used. Further, the drug 1) doesn’t work and 2) could be harmful.

The FDA panel argued MOV should be reconsidered after other drugs became available. That time has come.

3⃣ #MEDICARE. Last week, Merck sued the US government over a new law that will allow Medicare to negotiate certain drug prices — a common practice worldwide. Failure to negotiate is one reason a vial of insulin costs $300 in the US but $30 in Canada.

One of Merck’s reasons for suing is likely its cancer drug #Keytruda, upon which it relies to maintain yearly profits of US$14.5 billion. Among other complaints, Merck’s lawyers suggest the company’s ‘free-speech rights’ will be violated.

-

IN CONCLUSION, the for-profit health industry urgently needs reform to address

(1) inordinate profits on good drugs developed from public research

(2) bad drugs

(3) price gouging

Such practices have arguably done more than any media influencer to stoke public distrust in #science.

https://www.nytimes.com/2023/06/06/business/merck-medicare-drug-prices.html

One thing that occurs to me about the advantage of threads is that you can link to something new, with its own media preview, in each post component. Haven’t tried a long post here yet, but I assume it’s like elsewhere and limited to a single link preview or image(s)? Just a thought

Did not! Could you point to specific part? I’ll try to listen soon

Thanks a ton! Will try a single post version. (Totally new ignoramous here!)

Thanks and likewise! Totally new here too, just jumped right in without learning the ‘culture’ first. Oops!

Nasal swabs are thought best, but if your purpose in testing for #COVID19 is to ensure you’re negative and won’t spread it, then swab more.

I prefer nose, then throat and mouth.

Reason: the virus often starts in the throat before it ‘moves around’ over the course of infection.

Thanks a ton, friend! Will try to learn about that soon. (Accurately consider me an ignoramous for the time being!)

Thanks a ton!

Thanks so much! I just dove right in without much thought, but this is great! Also, is there a place to find explanations of feature? For example, what is ‘Broadcast’?

If you could point me to a good Damus how-to, I’d be very grateful!

In summary, the for-profit health industry urgently needs reform to address

1⃣inordinate profits on good drugs developed from public research

2⃣bad drugs

3⃣price gouging

Such practices have arguably done more than any media influencer to stoke public distrust in science. 12/12

One of #Merck’s reasons for suing is likely its cancer drug Keytruda, upon which it relies to maintain yearly profits of US$14.5 billion.

Among other complaints, Merck’s lawyers suggest the company’s ‘free-speech rights’ will be violated. 11/12

3⃣MEDICARE. Last week, #Merck sued the US government over a new law that will allow Medicare to negotiate certain drug prices — a common practice worldwide.

Failure to negotiate is one reason a vial of insulin costs $300 in the US but $30 in Canada. 10/12 https://www.nytimes.com/2023/06/06/business/merck-medicare-drug-prices.html

Updates on MOV mutations continue to be provided by Ryan Hisner on Twitter.

Further, as he explains, the drug 1) doesn’t work and 2) could be harmful.

The FDA panel argued MOV should be reconsidered after other drugs became available.

That time has come. 9/12

Concerns about MOV’s risks have sadly been validated.

For example, work by Theo Sanderson and colleagues shows elevated — but sublethal — mutations in viral genomes, consistent with MOV, in regions where it’s used. 8/12 https://www.medrxiv.org/content/10.1101/2023.01.26.23284998v2

Unfortunately, MOV was recommended 13-10.

Merck’s case to the FDA repeatedly confused mutation and selection, arguing that all drugs impose selection.

But the problem is mutation: MOV potentiates rare but impactful ‘black swan’ variants. 7/12 https://www.youtube.com/watch?v=fR9FNSJT64M

Weeks before the US #FDA decision on MOV, numerous scientists identified issues with Merck’s statistical analyses, the risks posed to individual patients, and the risks for viral evolution.

Sally Otto and I explained the viral evolution risk here. 6/12 https://virological.org/t/mutagenic-antivirals-the-evolutionary-risk-of-low-doses/768

2⃣MOLNUPIRAVIR (MOV). #Merck obtained emergency approval for MOV in December 2021 — just barely the first oral antiviral against COVID-19.

But MOV works by causing viral mutations, the raw material for new variants of concern. 5/12