For someone with a small hand, the Walther PPK (or PPK/S) is a good choice. It's a small automatic (made famous by Bond) chambered for a .380 cal round. Perfect for the bedside table, and home defense.

For a larger hand (most men) I really like Sig Sauer P226. It's really expensive, but highly reliable which is what you want in a home defense situation.

A sawed-off shotgun (Remington 870) loaded with 12-guage birdshot is also an excellent home defense weapon as you just need to point it in the general direction of your target. And the birdshot will prevent a lot of damage to your home, and prevent errant shots from impacting your neighbors.

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I've heard the argument that .380 offers less stopping power; stats from actual confrontations have shown a 9mm is much more likely to stop an attacker. And even a person with small weak hands can handle a 9mm with practice.

I'm not a pro so i don't know how much weight to put on this argument.

A .380 and a 9mm are virtually the same size. A .380 loaded with appropriate hollow-point rounds has plenty of stopping power in a confined space, like your living room.