Linoleic acid (LA) is a context-dependent and minor contributor to mitochondrial membrane health, with effects varying by cell type and age (Marei et al., 2012; Moran et al., 2001; Jeng et al., 2009). The fatty acid composition of animal products, including red meat, is significantly influenced by diet, highlighting the importance of food sourcing. Animals consuming corn and soy, particularly as soybean oil or roasted soybeans, exhibit increased LA levels in their muscle and fat (Alencar et al., 2021; Fang et al., 2009). For instance, pigs and beef cattle fed these diets show higher polyunsaturated fatty acids, including LA, while pasture-raised or wild animals have higher omega-3 levels and a more favorable omega-6 to omega-3 ratio (Zhao et al., 2012; Sergin et al., 2022). This illustrates that dietary sources profoundly affect the nutritional quality and health impacts of animal-derived foods (Wood et al., 2008; Koizumi et al., 1991). While increased vegetable oil consumption has elevated LA in human diets, its specific impact on human mitochondrial LA levels remains underexplored (Jandacek, 2017; Taha, 2020). Further research is necessary to understand the nuanced effects of LA on mitochondrial dynamics across different contexts and species (Pepe, 2005; Chen et al., 2023; Choque et al., 2013).
Argument 3 is where the rubber hits the road but it isn't laid out well enough for me to comment on extensively. AFAIK from 5 years of growing beef, most of it is finished with corn. Don't know if chicken, pork, eggs are naturally high in LA or if beef is naturally low. Curious as to why chronic inflammation, excessive calorie consumption, lack of movement, and high stress are not accounted for.
In text form:
Argument 1
Excess linoleic acid in mitochondrial membrane (MM) --> lower MM recycling rate
Lower MM recycle rate --> MM dysfunction
MM dysfunction --> Metabolic dysfunction
Metabolic dysfunction --> chronic disease
Argument 2
Low fat diet --> increased MM recycling
Low linoleic acid diet --> increased MM recycling
Proof for Argument 2:
Rice, sugar, fruit juice diet --> cured T2DM
Argument 3
Eggs, chicken, pork from animals that eat corn and soy --> increased linoleic acid in diet
Increased linoleic acid in diet --> excess linoleic acid in mitochondrial membrane (MM)
Red meat -X-> increased linoleic acid in diet
You're man of the house? The Provider and Protector? The spiritual leader?
Than take a stand. Your 8-year-old does not need an electronic device for Christmas. If you model doomscrolling then it's gonna be hard to sell that idea, lol. But leaders sell ideas. Children should reverence their parents; don't get in their way. And don't be a pushover.
Also your porn use is going to infect them.
Woke up at 2am, my brain knew someone said something I disagreed with on #Nostr.
When you preach #sleephygiene but also give in to the urge to check social media when you should be sleeping🤦🏻♂️ #hypocracy
Time for a couple-week #smbreak :)
Are there nonpathogenic infections?
Parasites can cause chronic localized inflammation, and this likely leads to the cancers associated with *some* parasites, like schistosomiasis and SCC of the bladder.
#Cancer is not one disease. Blanket statements like this are neither helpful, nor accurate.
Cutting off glucose is not completely absurd. There is decent evidence in certain cancers that this helps Just like chemo, radiation, immunotherapy, and exercise are not completely absurd.
And you're totally ignoring the whole theory of mitochondrial dysfunction.
No, no, no. That's not the hypothesis, that's not how prions work, and it doesn't make any sense.
The turbocancer hypothesis centers around incorporation of an amplification sequence (via retrotransposon) into the human genome.
Prions are misfolded proteins that induce a chain reaction inducing normal proteins to also misfold, thereby causing neurodegenerative disease of the central nervous system. The brain controls nerves that go to all parts of the body so it looks like the disease "spreads everywhere", but the prions themselves are not thought to.
Creative thinking is great but you can't just make up a new disease and new pathophysiology out of thin air. That's just as assinine as "flatten the curve."
It's a good night when you find someone who you disagree with, but whose writing and thoughts you appreciate and learn from. Thank you @nostr:nprofile1qqsx45lz5dyp3v2neq0533v0gnj3n8nmflydhcmczzsqph8rey9hwsqwsg534
Take a gander:
$14 / year subscription to Nostr isn't so bad 😄
This is just WOS, actual subscription is probably $25...yikes
But it's good money going to good people!
Rules are:
3 things you're grateful for, each day
No repeats within a 2-week period
Nobody is enforcing the rules 😂
For the next 379 days I'm going to keep a public #gratitude journal here on Nostr. It's something I recommend to most all patients who deal with chronic pain, and I've noticed myself being a little more negative than I'd like to be these days. So decided to put some skin in the game.
#gratitude2025 if you want to play along. I'll be zapping.
Most people I know (33/40 on a quick count) are using AI for search. I.e. use case #2 above.
Fair, didn't think of it as one but basically is